What is Pulmonary Arterial Hypertension (PAH)?

PAH is different from ordinary hypertension, which is high blood pressure throughout the body. In PAH, the high blood pressure is in the arteries between the heart and lungs. Healthy blood vessels are open and elastic. The blood vessels that go from the heart to the lungs, which are called the pulmonary arteries, are normally elastic. In patients with PAH, the pulmonary arteries become tight, thick, and stiff. This creates more resistance to blood flow.

The effects of PAH on the lungs
When blood travels through the lungs, it receives oxygen to carry to the rest of the body. In people who have PAH, the blood vessels in the lungs become too narrow. This makes it hard for the right side of the heart to pump blood through the lungs.

Healthy lungs
In a healthy person's lungs, the vessels are wide enough for the blood to flow freely through the lungs to collect oxygen to deliver to the rest of the body.

Affected lungs
In a person with PAH, the vessels in the lungs become narrowed, making it much more difficult for the blood to flow through them.

The effects of PAH on the heart
A heart affected by PAH has to work harder and harder to pump against these high pressures. Over time, this strain can cause the walls of the heart to thicken, and the right side of the heart to become enlarged, and less blood is able to flow through the lungs, resulting in less oxygen delivery throughout the body.

Click here to watch a video animation to learn more about PAH and see how Adcirca works in the body

Indication

Adcirca is a prescription medication used to treat pulmonary arterial hypertension (WHO Group 1) to improve exercise ability.

Important Safety Information for Adcirca

You should discuss all of your medical conditions and all medications with your doctor before starting Adcirca.

Do not take Adcirca if you take any medications that contain nitrates (often used for chest pain), as the combination could cause a sudden, unsafe drop in blood pressure.

Do not take Adcirca if you are allergic to tadalafil or any other ingredient in Adcirca.

If you experience chest pain after taking Adcirca, contact your doctor.

Adcirca is a type of medication called a PDE-5 inhibitor. Adcirca contains the same ingredient (tadalafil) as Cialis, which is used to treat erectile dysfunction (impotence). If you are taking Adcirca, do not take Cialis or other PDE-5 inhibitors.

PDE-5 inhibitors can cause blood vessels to widen, which may result in a decrease in blood pressure. If you have heart-disease or any problems with low blood pressure, tell your doctor before taking Adcirca, as these conditions may be affected by the action of Adcirca. If you have ever had blockage in the veins of your lungs, known as pulmonary veno-occlusive disease (PVOD), Adcirca is not recommended for you.

Do not take Adcirca if you are taking rifampin (an antibiotic for certain bacterial infections), or antifungal medications, such as ketoconazole and itraconazole. If you require treatment with both Adcirca and ritonavir (Norvir) at the same time, your dose of Adcirca will need to be adjusted. Taking Adcirca with alcohol, or blood pressure medications, such as alpha-blockers, may lower blood pressure and cause hypotension (fainting). Inform your doctor if you have kidney or liver problems before taking Adcirca.

In rare cases, men taking PDE-5 inhibitors (including tadalafil) for erectile dysfunction reported side effects such as a sudden decrease or loss of vision or hearing, or an erection lasting more than four hours. If you experience any of these side effects, seek medical attention right away.

The most common side effects of Adcirca are headache, muscle pain, getting red or hot in the face (flushing), nausea, pain in the arms, legs or back, upset stomach, stuffy or congested nose.

Click here for Full Prescribing Information and Patient Information or call 1-800-545-5979.

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Functional Classifications of PAH

This classification was created by the New York Heart Association (NYHA) to measure the degree of disease severity in patients with PAH. The World Health Organization (WHO) developed a similar functional class system that is also commonly used in assessing patients with PAH.


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Electronic Reprint System
Mobile™ ePrint

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Welcome to the electronic reprint system. Your Mobile™ ePrint is ready for download.

We recommend that you “Save” the file to your desktop for portability.

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To save your ePrint – Please follow these steps:

Step 1. To download the file, click on the Download File link provided below.

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